秋葵视频

秋葵视频
秋葵视频 Cancer Center

Structural Biology Shared Resource (SBSR)

The Structural Biology Shared Resource enables advanced atomic-level studies on the structure and function of cancer related molecules, macromolecules, and their interactions with drugs and biologicals.

Scheduling, Location, and Hours of Operation

Protein Purification Unit: Translational Biomedical Research Center (TBRC), 3rd floor
Cryo-EM facility: Health Research Center, Basement
Monday–Friday from 8 a.m.-5 p.m.

Services and Technologies

The SBSR consists of the Protein Purification unit and the Structure Determination unit. The Protein Purification unit produces homogeneous, high-quality proteins well suited for downstream biophysical studies and structure determination. The Structure Determination unit employs X-ray crystallography, Cryo-EM, and advanced AI-assisted analytical tools for structure determination and imaging.

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Protein Production
  • I26R New Brunswick incubators
  • Aeolus compact CO2 incubators
  • Guava easyCyte cytometer
  • Optima XPN-80
  • NGC Bio-Rad
  • Akta Start
  • Shimatzu HPLC
  • Agilent 1260 Infinity
  • Thermo Ultimate 3000
  • Agilent Cary Eclipse
Cryo-EM
  • PELCO easiGlow
  • Thermo Fisher Glacios
  • Falcon 4 detector
  • Ceta-D Camera
  • Selectris
  • GPU workstations
Structural Biology Shared Resource

iLab Requests and Support

Access the links below to learn how to register for iLab and submit requests.

Leadership

headshot

Wei Liu, PhD

Director, Structural Biology Shared Resource (SBSR)

weiliu@mcw.edu

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Notable Publications

 (Geng T, Sun Q, He J, Chen Y, Cheng W, Shen J, Liu B, Zhang M, Wang S, Asan K, Song M, Gao Q, Song Y, Liu R, Liu X, Ding Y, Jing A, Ye X, Ren H, Zeng K, Zhou Y, Zhang B, Ma S, Liu W, Liu S, Ji J) Cell Signal 2024 Jul;119:111180. PMID: 38642782; DOI: 10.1016/j.cellsig.2024.111180; Scopus ID: 2-s2.0-85190884720

 (Ji J, Jing A, Ding Y, Ma X, Qian Q, Geng T, Cheng W, Zhang M, Sun Q, Ma S, Wang X, Yuan Q, Xu M, Qin J, Ma L, Yang J, He J, Du Q, Xia M, Xu Y, Chen Z, Zhu L, Liu W, Liu S, Liu B) Cell Death Dis 2024 Jan 11;15(1):33). PMID: 38212299; PMCID: PMC10784456; DOI: 10.1038/s41419-024-06421-2; Scopus ID: 2-s2.0-85182091692

(Ji J, Qian Q, Cheng W, Ye X, Jing A, Ma S, Ding Y, Ma X, Wang Y, Sun Q, Wang X, Chen Y, Zhu L, Yuan Q, Xu M, Qin J, Ma L, Yang J, Zhang M, Geng T, Wang S, Wang D, Song Y, Zhang B, Xu Y, Xu L, Liu S, Liu W, Liu B) Cell Death Dis 2024 May 13;15(5):332. PMID: 38740744; PMCID: PMC11091054; DOI: 10.1038/s41419-024-06713-7; Scopus ID: 2-s2.0-85192951272 

(Tan B, Liu C, Li K, Jadhav P, Lambrinidis G, Zhu L, Olson L, Tan H, Wen Y, Kolocouris A, Liu W, Wang J) J Med Chem 2023 Nov 09;66(21):14544-14563. PMID: 37857371; DOI: 10.1021/acs.jmedchem.3c00995; Scopus ID: 2-s2.0-85176509223

(Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G) Sci Adv 2022 Dec 23;8(51):eadd3709. PMID: 36563137; PMCID: PMC9788782; DOI: 10.1126/sciadv.add3709; Scopus ID: 2-s2.0-85144637416

 (Jurutka PW, di Martino O, Reshi S, Mallick S, Sausedo MA, Moen GA, Lee IJ, Ivan DJ, Krall TD, Peoples SJ, Perez A, Tromba L, Le A, Khadka I, Petros R, Savage BM, Salama E, Salama J, Ziller JW, Noh Y, Lee MY, Liu W, Welch JS, Marshall PA, Wagner CE) Int J Mol Sci 2022 Dec 19;23(24). PMID: 36555852; PMCID: PMC9782500; DOI: 10.3390/ijms232416213; Scopus ID: 2-s2.0-85144580245

(Lyapina E, Marin E, Gusach A, Orekhov P, Gerasimov A, Luginina A, Vakhrameev D, Ergasheva M, Kovaleva M, Khusainov G, Khorn P, Shevtsov M, Kovalev K, Bukhdruker S, Okhrimenko I, Popov P, Hu H, Weierstall U, Liu W, Cho Y, Gushchin I, Rogachev A, Bourenkov G, Park S, Park G, Hyun HJ, Park J, Gordeliy V, Borshchevskiy V, Mishin A, Cherezov V) Nat Commun 2022 Aug 12;13(1):4736. PMID: 35961984; PMCID: PMC9374744; DOI: 10.1038/s41467-022-32447-1; Scopus ID: 2-s2.0-85135832975

(Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY) Nat Commun 2022 Jul 14;13(1):4095. PMID: 35835792; PMCID: PMC9283524; DOI: 10.1038/s41467-022-31823-1; Scopus ID: 2-s2.0-85134147752